Dynasore ≥98% (durch HPLC), Millipore®
Lieferant: Merck Millipore Calbiochem
Synonyme:
N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide, 3-Hydroxynaphthalene-2-carboxylic acid (3,4-Dihydroxybenzylidene)hydrazide
Dynasore, also known as Dynamin inhibitor I, is a cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. It has no significant effect against two other small GTPases, MxA and Cdc42.
- Pale yellow solid
- Packaged under inert gas
- Protect from light
Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain.
Formel:
C₁₈H₁₄N₂O₄ Molecular Weight: 322,32 g/mol Lagertemperatur: Kühlschrank |
MDL:
MFCD00292551 CAS-Nummer: 304448-55-3 |
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