5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione ≥99% (durch HPLC), Calbiochem®, Sigma-Aldrich®

Lieferant: Merck Millipore Calbiochem

Synonyme: A1676390, Eg5 Inhibitor IV, VS-83

M-Clarity™ Qualitätsstufe = MQ100

324623-5
324623-5EA 304 EUR
324623-5
5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione ≥99% (durch HPLC), Calbiochem®, Sigma-Aldrich®
5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione

The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.


A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.


Verpackung: Packaged under inert gas

Formel: C₁₄H₁₁FN₂OS
Molecular Weight: 274,31 g/mol
Lagertemperatur: Gefrierschrank
CAS-Nummer: 909250-29-9

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