Erastin ≥98% (durch HPLC), fest, Calbiochem®, Sigma-Aldrich®

Lieferant: Merck Millipore Calbiochem

Synonyme: 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one, 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one

M-Clarity™ Qualitätsstufe = MQ100

329600-5
329600-5EA 199 EUR
329600-5
Erastin ≥98% (durch HPLC), fest, Calbiochem®, Sigma-Aldrich®
Erastin

Antitumor agent


A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).


Verpackung: Packaged under inert gas

Formel: C₃₀H₃₁ClN₄O₄
Molecular Weight: 547,052 g/mol
Lagertemperatur: Gefrierschrank
MDL: MFCD09837984
CAS-Nummer: 571203-78-6

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