Erastin ≥98% (durch HPLC), fest, Calbiochem®, Sigma-Aldrich®
Lieferant: Merck Millipore Calbiochem
Synonyme:
2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one, 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one
M-Clarity™ Qualitätsstufe = MQ100
Antitumor agent
A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
Verpackung: Packaged under inert gas
Formel:
C₃₀H₃₁ClN₄O₄ Molecular Weight: 547,052 g/mol Lagertemperatur: Gefrierschrank |
MDL:
MFCD09837984 CAS-Nummer: 571203-78-6 |
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