GW 9508 ≥98% (durch HPLC), Calbiochem®, Sigma-Aldrich®
Lieferant: Merck Millipore Calbiochem
Synonyme:
GPR40 Agonist, GW9508, 4-[[(3-Phenoxyphenyl)methyl]amino]benzene propanoic acid, GW-9508, 3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acid, 3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, Free Fatty Acid Receptor 1 Agonist I, FFA1 Agonist I
M-Clarity™ Qualitätsstufe = MQ100
The GPR40 Agonist, also referenced under CAS 885101-89-3, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Cell Signaling applications.
General description
A cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GPR40 (EC50 ~50 nM) with much reduced activity towards family members GPR120 (EC50 ~3.5 µM), GPR41/GPR43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
A cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40 (EC50 ~50 nM) with much reduced activity towards family members GRP120 (EC50 ~3.5 µM), GRP41/GRP43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
Verpackung: Packaged under inert gas
Formel:
C₂₂H₂₁NO₃ Molecular Weight: 347,414 g/mol Lagertemperatur: Kühlschrank |
MDL:
MFCD09753282 CAS-Nummer: 885101-89-3 |
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