Organic reference standard, Hyperforin (dicyclohexylammonium) salt, analytical standard, Supelco®

Lieferant: Merck

42891-5MG
42891-5MGEA 460 EUR
42891-5MG
Organic reference standard, Hyperforin (dicyclohexylammonium) salt, analytical standard, Supelco®
Standards Organische Standards

Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6.


It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found it to have neuroprotective effects against Alzheimer′s disease (AD) neuropathology.

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