SD-169 ≥97% (durch HPLC), Calbiochem®, Sigma-Aldrich®
Lieferant: Merck Millipore Calbiochem
Synonyme:
p38 MAP Kinase Inhibitor VII, 1H-indole-5-carboxamide, Indole-5-carboxamide
M-Clarity™ Qualitätsstufe = MQ100
The p38 MAP Kinase Inhibitor VII, SD-169, also referenced under CAS 1670-87-7, controls the biological activity of p38 MAP Kinase.
General description
A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
Verpackung: Packaged under inert gas
Formel:
C₉H₈N₂O Molecular Weight: 160,17 g/mol Lagertemperatur: Kühlschrank |
MDL:
MFCD07779486 CAS-Nummer: 1670-87-7 |
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