C-4 ≥95% (durch HPLC), Calbiochem®, Sigma-Aldrich®
Lieferant: Merck Millipore Calbiochem
Synonyme:
(E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide,, P-Glycoprotein Inhibitor
M-Clarity™ Qualitätsstufe = MQ100
The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.
General description
A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
Verpackung: Packaged under inert gas
Formel:
C₂₃H₁₈ClNO₄ Molecular Weight: 407,85 g/mol Lagertemperatur: Kühlschrank |
CAS-Nummer:
864426-22-2 |
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