L-779450 ≥97% (durch HPLC), Calbiochem®, Sigma-Aldrich®
Lieferant: Merck Millipore Calbiochem
Synonyme:
2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol, Raf Kinase Inhibitor IV, L 779450, 2-Chloro-5-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)phenol, 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L779450
M-Clarity™ Qualitätsstufe = MQ100
The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
General description
A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM & Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
Verpackung: Packaged under inert gas
Formel:
C₂₀H₁₄ClN₃O Molecular Weight: 347,80 g/mol Lagertemperatur: Kühlschrank |
MDL:
MFCD12828750 CAS-Nummer: 303727-31-3 |
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