Anti-ATBF1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Lieferant: Bioss
BS-11805R-A680
BOSSBS-11805R-A680EA 890 EUR
BOSSBS-11805R-A680
Anti-ATBF1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Antikörper
AT-motif binding factor 1 (ATBF1) binds to the AT-rich core sequence element in the human a-fetoprotein enhancer. Alternative splicing generates the ATBF1-A and ATBF1-B. While ATBF1-A contains a 920-amino acid extension at the N-terminus, both ATBF1-A and ATBF1-B contain 4 DNA-binding homeobox domains. Additionally, ATBF1-A contains 23 zinc finger motifs while ATBF1-B contains 18 zinc finger motifs. The N-terminal extension unique to ATBF1-A has transcriptional repressor activity. In the small intestine, ATBF1-A inhibits expression of the brushborder enzyme aminopeptidase-N through direct binding to the AT motif element. Besides functioning in transcription regulation, ATBF1 also functions in ATPase activity. ATPase activity associated with ATBF1-A is DNA/RNA-dependent and requires both homeobox domains and zinc finger motifs. ATBF1 is highly expressed in spleen and brain tissues. The gene encoding human ATBF1 maps to chromosome 16q22.3-q23.1.

Type: Primary
Antigen: ATBF1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 301-400/3703
Host: Rabbit
Isotype: IgG
Reactivity: Rat
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