Anti-BAGE2 Rabbit Polyclonal Antibody (Cy7®)

Lieferant: Bioss
BS-9114R-CY7
BOSSBS-9114R-CY7EA 893 EUR
BOSSBS-9114R-CY7
Anti-BAGE2 Rabbit Polyclonal Antibody (Cy7®)
Antikörper
Members of the BAGE gene family encode antigens that are recognized by cytotoxic T lymphocytes and are also known as CT (cancer/testis) antigens. Generated by juxtacentromeric shuffling of the MLL3 gene, the ancestral BAGE gene was expanded by acrocentric exchanges and/or juxtacentromeric movements.Generally, BAGE proteins are silent in all normal tissues with the exception of testis. BAGE2 and BAGE 3 (B melanoma antigen 2 and 3, respectively), also known as Cancer/testis antigen 2.2 and 2.3 (respectively), are 109 amino acid secreted proteins that are expressed in 22% of melanomas, lung and bladder carcinomas, and are also expressed in normal testis tissue. Like the genes encoding MAGE proteins, BAGE genes are most likely silenced by DNA methylation and/or chromatin compaction in normal tissues other than testis.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: BAGE2
Clonality: Polyclonal
Clone:
Conjugation: Cy7®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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