Epoprosterol sodium ≥99%, weißes Pulver
Lieferant: MP Biomedicals
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Achtung
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Synonyme:
Prostaglandin I2 sodium salt, Prostaglandin I2
PGI2 is synthesized primarily in vascular endothelial cells. It is a potent inhibitor of platelet aggregation, relaxes vascular smooth muscle, and also increases cyclic AMP concentration in human platelets.
Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.
Prostaglandin I2 sodium salt stimulates platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.
Solutions of PGI2 at physiologic pH and room temperature will have a half-life from 1 to 12 minutes depending on buffer concentration. Half-life under physiological conditions is 2 minutes.
Bitte beachten Research Use Only (RUO). Store Desiccated.
Formel:
C₂₀H₃₁NaO₅ Molecular Weight: 374,453 g/mol Lagertemperatur: Gefrierschrank |
MDL:
MFCD00135629 CAS-Nummer: 61849-14-7 |
Spezifikation Testergebnisse
Identity Test | Passes |
Purity | ≥99% |
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