Paromomycin sulphate ≥97%, Pulver
Lieferant: MP Biomedicals
Synonyme:
(2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulphate(1:x)
Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against gram-negative bacteria, gram-positive bacteria, some protozoan species, and limited anti helminth. It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit cryptosporidium infection of a human enterocyte cell line.
Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Soluble in water (25% w/v - light opalescent solution).
Formel:
C₂₃H₄₅N₅O₁₄·H₂SO₄ Molecular Weight: 615,6 g/mol |
MDL:
MFCD00079278 CAS-Nummer: 1263-89-4 |
Spezifikation Testergebnisse
Form | White Powder |
Storage | Store at Room Temperature (15 - 30 °C) |
Potency |
|
Typical Working Concentration | 100 mg/L |
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