DTBP (Dimethyl 3,3′-dithiopropionimidate dihydrochloride), Pierce™

Lieferant: Thermo Fisher Scientific
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Synonyme: Wang/Richard Reagenz, DTBP

20665
PIER20665EA 266 EUR
PIER20665
DTBP (Dimethyl 3,3′-dithiopropionimidate dihydrochloride), Pierce™
DTBP (Dimethyl 3,3′-dithiopropionimidate dihydrochloride)

Thermo Scientific Pierce DTBP is dimethyl 3,3'-dithiobispropionimidate, a crosslinker that contains amine-reactive imidoester groups around an 8-atom spacer arm, whose central disulfide bond can be cleaved with reducing agents.


  • Reactive groups: imidoester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Imidoester reacts rapidly with any primary amine-containing molecule to form amidine bonds
  • Cleavable by reduction of spacer arm disulfide bond with DTT, TCEP or other reducing agents
  • Compare to DMS (non-cleavable)
  • Water-soluble


Dimethyl dithiobispropionimidate (DTBP) is a homobifunctional, cleavable and membrane permeable crosslinker. It contains an amine-reactive imidoester at each end of an 8-atom spacer arm. Imidoesters react with primary amines at pH 8-10 to form stable amidine bonds. The amidine is protonated and therefore, like the lysine it modified, has a positive charge at physiological pH. Proteins, including antibodies, generally have several primary amines in the side chain of lysine (K) residues and the N-terminus of each polypeptide that are available as targets for imidoester crosslinking reagents.


Bitte beachten For Research Use Only. Not for use in diagnostic procedures.

Formel: C₈H₁₆N₂O₂S₂·2HCl
Molecular Weight: 309,28 g/mol
Lagertemperatur: Kühlschrank
MDL: MFCD00043245
CAS-Nummer: 38285-78-8

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Spezifikation Testergebnisse

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Reactive Moiety Imidoester
Spacer Cleavable, Mid-Length
Form Powder
Quantity 1 g
Type Crosslinker
Solubility Water

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