PDPH ((3-(2-pyridyldithio)propionyl hydrazide)), Pierce™

Lieferant: Thermo Fisher Scientific

Synonyme: PDPH

22301
PIER22301EA 262 EUR
PIER22301
PDPH ((3-(2-pyridyldithio)propionyl hydrazide)), Pierce™
PDPH ((3-(2-pyridyldithio)propionyl hydrazide))

Thermo Scientific Pierce PDPH is a short, pyridyldithiol-and-hydrazide crosslinker for reversibly conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).


  • Reactive groups: pyridyldisulfide and hydrazide
  • Reactive toward: sulfhydryl groups and carbonyl (aldehyde) groups
  • Short (9.2A), sulfhydryl-to-aldehyde crosslinker with disulfide bond spacer arm (cleavable)
  • Pyridyldithiol group results in attachment to sulfhydryls via disulfide bond, which can be cleaved with DTT, TCEP or other reducing agents
  • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
  • Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
  • Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups


Bitte beachten For Research Use Only. Not for use in diagnostic procedures.

Formel: C₈N₃S₂OH₁₁
Molecular Weight: 229.32 g/mol
Lagertemperatur: Kühlschrank
MDL: MFCD00467204
CAS-Nummer: 115616-51-8

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Spezifikation Testergebnisse

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, Pyridyldisulfide
Spacer Cleavable, Short
Form Powder
Quantity 50 mg
Type Crosslinker
Solubility DMF, DMSO


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