6-Maleinimido-capronsäure-N-succinimidylester (EMCS), Pierce™

Lieferant: Thermo Fisher Scientific

Synonyme: 2,5-Dioxopyrrolidin-1-yl-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate

22308
PIER22308EA 322 EUR
PIER22308
6-Maleinimido-capronsäure-N-succinimidylester (EMCS), Pierce™
6-Maleinimido-capronsäure-N-succinimidylester (EMCS)

Thermo Scientific Pierce EMCS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).


  • Reactive groups: NHS ester and maleimide
  • Reactive towards: amino and sulfhydryl groups
  • C6-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
  • NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
  • Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-EMCS
  • Increased sphere of coupling vs. GMBS
  • Short aliphatic spacer has low potential for eliciting an immune response


Bitte beachten For Research Use Only. Not for use in diagnostic procedures.

Formel: C₁₄H₁₆N₂O₆
Molecular Weight: 308,29 g/mol
Lagertemperatur: Kühlschrank
MDL: MFCD00043043
CAS-Nummer: 55750-63-5

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Spezifikation Testergebnisse

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, NHS Ester
Spacer Short
Form Powder
Quantity 50 mg
Type Crosslinker
Solubility DMF, DMSO

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