6-Maleinimido-capronsäure-N-succinimidylester (EMCS), Pierce™
Lieferant: Thermo Fisher Scientific
Synonyme:
2,5-Dioxopyrrolidin-1-yl-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
22308
PIER22308EA
322
EUR
PIER22308
6-Maleinimido-capronsäure-N-succinimidylester (EMCS), Pierce™
6-Maleinimido-capronsäure-N-succinimidylester (EMCS)
Thermo Scientific Pierce EMCS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).
- Reactive groups: NHS ester and maleimide
- Reactive towards: amino and sulfhydryl groups
- C6-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
- NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
- Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-EMCS
- Increased sphere of coupling vs. GMBS
- Short aliphatic spacer has low potential for eliciting an immune response
Bitte beachten For Research Use Only. Not for use in diagnostic procedures.
Formel:
C₁₄H₁₆N₂O₆ Molecular Weight: 308,29 g/mol Lagertemperatur: Kühlschrank |
MDL:
MFCD00043043 CAS-Nummer: 55750-63-5 |
Spezifikation Testergebnisse
Product Line | Pierce™ |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Reactive Moiety | Maleimide, NHS Ester |
Spacer | Short |
Form | Powder |
Quantity | 50 mg |
Type | Crosslinker |
Solubility | DMF, DMSO |
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