2-Iminothiolane hydrochloride (Traut's Reagent), Pierce™

Lieferant: Thermo Fisher Scientific

Synonyme: 2-IT HCl, 2-Iminothiolane hydrochloride, 2-Thiolanimine hydrochloride, 2-IT

26101
PIER26101EA 285 EUR
PIER26101
2-Iminothiolane hydrochloride (Traut's Reagent), Pierce™
2-Iminothiolane hydrochloride (Traut's Reagent)

Pierce™ Traut's Reagent (2-Iminothiolane or 2-IT) is a cyclic thioimidate compound for thiolation (sulfhydryl addition)


  • Simple, one-step conversion of amines to sulfhydryls
  • Selective and spontaneous modification of primary amines at pH 7 to 10
  • Preserves positive charge to maintain protein solubility


Traut’s Reagent reacts with primary amines (-NH2) to introduce sulfhydryl (-SH) groups while maintaining charge properties similar to the original amino group. Once added, sulfhydryl groups may be specifically targeted for reaction in a variety of useful labeling, cross-linking, and immobilisation procedures.

Formel: C₄H₈ClNS
Molecular Weight: 137.625 g/mol
Lagertemperatur: Kühlschrank
MDL: MFCD00039013
CAS-Nummer: 4781-83-3

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