Human Recombinant Proprotein Convertase 9 (from Cells)

Lieferant: ProSci Inc.

91-780
PRSI91-780EA 588 EUR
PRSI91-780
Human Recombinant Proprotein Convertase 9 (from Cells)
Enzyme

Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily.


This recombinant protein can be used for biological assays. For research use only.


Fusion-Tag: C-6 His tag


PCSK9 is synthesised as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

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