SPB (Succinimidyl-[4-(psoralen-8-yloxy)]butyrate), Sigma-Aldrich®

Lieferant: Merck


M-Clarity™ Qualitätsstufe = MQ100

803545-50MG
SIAL803545-50MGEA 310 EUR
SIAL803545-50MG
SPB (Succinimidyl-[4-(psoralen-8-yloxy)]butyrate), Sigma-Aldrich®
SPB (Succinimidyl-[4-(psoralen-8-yloxy)]butyrate)

SPB is an amine-reactive and photoreactive heterobifunctional crosslinking reagent. The photoreactive psoralen group provides much greater covalent insertion yields than phenyl azide-containing compounds, which makes this reagent a superior alternative to typical photoreactive NHS-ester crosslinkers. The psoralen tricyclic planar ring system intercalates into double-stranded, and to a lesser extent, single-stranded, DNA, RNA, PCR products, cDNA or oligonucleotides. It also can be used with agarose gel-purified oligonucleotides because the presence of agarose does not interfere with the coupling reaction. The nucleic acid labeling site of the psoralen group (the 5,6 double bond in thymine residues) does not interfere with subsequent hybridization reactions, creating a highly-sensitive direct labeling alternative to radioactive probes.


  • Reactive groups: NHS ester and psoralen
  • Reactive toward: amino groups and thymine
  • DNA intercalating agent and nucleic acid probe
  • Reagent for photo-immobilization to microplates


Bitte beachten This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.

Formel: C₁₉H₁₅NO₈
Molecular Weight: 385,32 g/mol
Schmelzpunkt: 177…178°C
Lagertemperatur: Kühlschrank
MDL: MFCD29041827
CAS-Nummer: 858128-57-1

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