Cyrene™/γ-Valerolactone Mischung, BioRenewable DMF and NMP substitute, Sigma-Aldrich®

Lieferant: Merck
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Synonyme: GVL Blend, Cyrene solution, γ-Valerolactone Cyrene™ solution, Cyrene™ γ-valerolactone solution, γ-Valerolactone solution

920207-1L
SIAL920207-1LEA 208 EUR
SIAL920207-1L
Cyrene™/γ-Valerolactone Mischung, BioRenewable DMF and NMP substitute, Sigma-Aldrich®
Cyrene™/γ-Valerolactone

Cyrene™ γ-Valerolactone Blend is specially formulated for use in automated processes and applications where lower viscosity is required, making it easier to handle while maintaining high yields.


  • Independently certified as 100% renewable carbon
  • Closer physical properties of NMP and DMF while maintaining high reaction yields
  • Sustainably produced and environmentally less hazardous than more traditional petroleum aprotic solvents
  • Both Cyrene and GVL are also much safer for handling without the genotoxic concerns of other solvents
  • It has a lower viscosity than neat Cyrene making it more optimized for automated processes


This Cyrene™ blend is an alternative for NMP and DMF in many cross-coupling reactions. Neither Cyrene™ nor γ-Valerolactone have any genotoxic or mutagenic concerns associated with their use, making them much safer alternatives to traditional aprotic solvents. This new blend is part of our Biorenewable product line, meaning that it is made from renewable resources and does not compete with food resources for its production, making it more environmentally sustainable for the future. The material has also been independently certified as 100% renewable carbon.

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Spezifikation Testergebnisse

Appearance (Color) Colorless to Yellow
Appearance (Form) Liquid
Component #1: Cyrene 48.0 - 52.0% wt
Component #2: Gamma-Valerolactone 48.0 - 52.0% wt
BioRenewable Carbon ≥70%

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