Brefeldin A 10 mg/ml in DMSO (aus Penicillium brefeldianum) ≥98,00% (durch HPLC) anwendungsbereit, Sigma-Aldrich®
Lieferant: Merck
Synonyme:
(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one, Brefeldin A, natural
M-Clarity™ Qualitätsstufe = MQ200
Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. The ester derivatives of BFA exhibit anti-cancer properties.
Hygroscopic. Soluble in DMSO (10 mg/ml).
Sterility: 0,2 μm filtered
Bitte beachten Store under inert gas. Storage class (TRGS 510): Combustible liquids
Formel:
C₁₆H₂₄O₄ Molecular Weight: 280,4 g/mol Lagertemperatur: Kühlschrank |
MDL:
MFCD00083258 CAS-Nummer: 20350-15-6 |
Spezifikation Testergebnisse
Concentration | 10.000 - 10.500 mg/ml |
Purity (HPLC) | ≥98.00% |
Vapor Pressure | 0.56 hPa ( 20 °C) |
Autoignition Temperature | 301 °C |
Antibiotic Activity Spectrum | Neoplastics |
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