2-Iminothiolane hydrochloride (Traut's Reagent) (synthetisch), Pulver

Lieferant: MP Biomedicals

Synonyme: 2-IT HCl, 2-Iminothiolane hydrochloride, 2-Thiolanimine hydrochloride, 2-IT

0215131980 0215131990
ICNA0215131980EA 95.4 EUR
ICNA0215131980 ICNA0215131990
2-Iminothiolane hydrochloride (Traut's Reagent) (synthetisch), Pulver
2-Iminothiolane hydrochloride (Traut's Reagent)

2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking.


It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.


Soluble in water (100 mg/ml) and methanol.

Formel: C₄H₈ClNS
Molecular Weight: 137.625 g/mol
Lagertemperatur: Kühlschrank
MDL: MFCD00039013
CAS-Nummer: 4781-83-3

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