Anti-GPC3 Mouse Monoclonal Antibody (CF405S) [clone: 1G12]

Lieferant: Biotium

BNC040862-500EA 530 EUR
BNC040862-500 BNC040862-100
Anti-GPC3 Mouse Monoclonal Antibody (CF405S) [clone: 1G12]
Antikörper
Recognizes a protein, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

Type: Primary
Antigen: GPC3
Clonality: Monoclonal
Clone: 1G12
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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