Natriumcholat ≥98,5%, weißes Pulver
Lieferant: MP Biomedicals
Synonyme:
Natrium-3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoat, Natrium-3α,7α,12α-trihydroxy-5β-cholanoat, 3α,7α,12α-Trihydroxycholan-24-säure Natriumsalz, 3α,7α,12α-Trihydroxycholansäure Natriumsalz, 3α,7α,12α-Trihydroxy-5β-cholan-24-säure Natriumsalz, Cholsäure Natriumsalz, 3α,7α,12α-Trihydroxy-5β-cholansäure Natriumsalz
Cholic acid is a biochemical solubilizing agent (a non-ionic, non-denaturing detergent). Occurs inconjugation with glycine or taurine in bile of most vertebrates.
- Critical Micelle Concentration (CMC): 14mM
Cholic acid is used in the solubilization of membrane-bound proteins in their native state. It is a component for the preparation of liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.
Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.
Cholic acid is a biochemical solubilising agent (a non-ionic, non-denaturing detergent). Occurs inconjugation with glycine or taurine in bile of most vertebrates.
Soluble in water (100 mg/ml). Soluble in ethanol (40 mg/ml - clear, colorless solution).
|
Formel:
C₂₄H₃₉NaO₅ Molecular Weight: 430,56 g/mol Schmelzpunkt: 198 °C Lagertemperatur: Raumtemperatur |
MDL:
MFCD00150749 CAS-Nummer: 361-09-1 EINECS: 206-643-5 |
Spezifikation Testergebnisse
| Identity Test | Passes |
| Purity (HPLC) | ≥98,5% |
| Loss on Drying | ≤5% |
| pH (2% aq soln) | 7,5 - 9,0 |
| Solubility (2% aq soln) | Clear and Colorless |
| Sodium Deoxycholate | ≤1,5% |
| Heavy Metals | ≤50 ppm |
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