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Anti-DNMT1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Beschreibung: DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Artikel-Nr: BOSSBS-5296R-A555
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-0301R-A680

Anti-Dnmt3 Beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Beschreibung: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
Artikel-Nr: BOSSBS-0301R-A680
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-0497R-A488

Anti-DNMT3A Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Beschreibung: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Artikel-Nr: BOSSBS-0497R-A488
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-5713R-A647

Anti-HOXA5 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Beschreibung: HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
Artikel-Nr: BOSSBS-5713R-A647
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-5998R-A750

Anti-DAB2IP Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Beschreibung: DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers. It also interacts with MAP3K5 to disrupt the association of MAP3K5 with the inhibitory 14-3-3 complex.
Artikel-Nr: BOSSBS-5998R-A750
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-5998R-A647

Anti-DAB2IP Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Beschreibung: DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers. It also interacts with MAP3K5 to disrupt the association of MAP3K5 with the inhibitory 14-3-3 complex.
Artikel-Nr: BOSSBS-5998R-A647
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-13025R-A647

Anti-TRDMT1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Beschreibung: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
Artikel-Nr: BOSSBS-13025R-A647
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-13025R-A555

Anti-TRDMT1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Beschreibung: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
Artikel-Nr: BOSSBS-13025R-A555
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-11670R-A350

Anti-SETDB1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Beschreibung: ESET is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.
Artikel-Nr: BOSSBS-11670R-A350
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-2396R-A488

Anti-GNMT Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Beschreibung: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Artikel-Nr: BOSSBS-2396R-A488
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-5713R-A680

Anti-HOXA5 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Beschreibung: HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
Artikel-Nr: BOSSBS-5713R-A680
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-10228R-A750

Anti-HINT1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Beschreibung: The protein encoded by this gene can hydrolyse substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumour suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene.
Artikel-Nr: BOSSBS-10228R-A750
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-6062R-A750

Anti-PRDM2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Beschreibung: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Artikel-Nr: BOSSBS-6062R-A750
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-2396R-A750

Anti-GNMT Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Beschreibung: Catalyses the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Artikel-Nr: BOSSBS-2396R-A750
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-6016R-A750

Anti-RBBP5 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Beschreibung: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Artikel-Nr: BOSSBS-6016R-A750
VE: 1 * 100 µl
Lieferant: Bioss
Image Unavailable-BOSSBS-13572R-A647

Anti-ZBTB38 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Beschreibung: The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types.
Artikel-Nr: BOSSBS-13572R-A647
VE: 1 * 100 µl
Lieferant: Bioss
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