Anti-CASP8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-0052R-A750
BOSSBS-0052R-A750EA 899 EUR
BOSSBS-0052R-A750
Anti-CASP8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP1. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyses the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.

Type: Primary
Antigen: CASP8
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 411-482/482
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Pig, Sheep, Monkey
Bestellen

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mehr About VWR