Anti-SOCS1 Rabbit Polyclonal Antibody (Cy3®)

Lieferant: Bioss
BS-0113R-CY3
BOSSBS-0113R-CY3EA 893 EUR
BOSSBS-0113R-CY3
Anti-SOCS1 Rabbit Polyclonal Antibody (Cy3®)
Antikörper
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: SOCS1
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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