Anti-NAMPT Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Lieferant: Bioss
BS-0272R-A488
BOSSBS-0272R-A488EA 893 EUR
BOSSBS-0272R-A488
Anti-NAMPT Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Antikörper
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: NAMPT
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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