Anti-DNMT3A Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Lieferant: Bioss
BS-0497R-FITC
BOSSBS-0497R-FITCEA 909 EUR
BOSSBS-0497R-FITC
Anti-DNMT3A Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Antikörper
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: DNMT3A
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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