Anti-IKK alpha / beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Lieferant: Bioss
BS-10123R-A680
BOSSBS-10123R-A680EA 890 EUR
BOSSBS-10123R-A680
Anti-IKK alpha / beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Antikörper
IKK Alpha/IKK beta is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquitination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.

Type: Primary
Antigen: IKK alpha / beta
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 151-250/756
Host: Rabbit
Isotype: IgG
Reactivity: Mouse
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