Anti-HSP 40-4/HDJ2/DNAJA1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Lieferant: Bioss
BS-11277R-A350
BOSSBS-11277R-A350EA 893 EUR
BOSSBS-11277R-A350
Anti-HSP 40-4/HDJ2/DNAJA1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Antikörper
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: HSP 40-4/HDJ2/DNAJA1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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