Anti-BBS9 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-11511R-A750
BOSSBS-11511R-A750EA 890 EUR
BOSSBS-11511R-A750
Anti-BBS9 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localisation.

Type: Primary
Antigen: BBS9
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 244-320/887
Host: Rabbit
Isotype: IgG
Reactivity: Rat
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