Anti-RAPGEF5 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Lieferant: Bioss
BS-11582R-A350
BOSSBS-11582R-A350EA 893 EUR
BOSSBS-11582R-A350
Anti-RAPGEF5 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Antikörper
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: RAPGEF5
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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