Anti-NDUFS7 Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)

Lieferant: Bioss
BS-11734R-A750
BOSSBS-11734R-A750EA 890 EUR
BOSSBS-11734R-A750
Anti-NDUFS7 Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)
Antikörper
Located in the mitochondrial inner membrane, mitochondrial complex I is the first and largest enzyme in the electron transport chain of oxidative phosphorylation. By oxidising NADH that is produced in the Krebs cycle, this complex utilises the two electrons to reduce ubiquinone to ubiquinol, thereby initiating the passage of electrons to successive complexes and ultimately leading to the reduction of oxygen to water. Mitochondrial complex I consists of over 40 subunits and is of considerable clinical interest Zince defects in any of the subunits can lead to various myopathies and neuropathies. As a subunit of mitochondrial complex I, NDUFS7 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 7), also designated NADH-ubiquinone oxidoreductase 20 kDa subunit, is a 213 amino acid protein that is suggested to be required for catalytic activity. Defects in the gene encoding NDUFS7 are the cause of Leigh syndrome, a severe neurological disorder that is characterised by bilaterally symmetrical necrotic lesions in subcortical brain regions.

Type: Primary
Antigen: NDUFS7
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-160/213
Host: Rabbit
Isotype: IgG
Reactivity: Mouse
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