Anti-SPR/Sepiapterin reductase Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-11784R-A750
BOSSBS-11784R-A750EA 890 EUR
BOSSBS-11784R-A750
Anti-SPR/Sepiapterin reductase Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyses the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson's Disease (PD) patients, suggesting that SPR may play a role in PD.

Type: Primary
Antigen: SPR/Sepiapterin reductase
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-200/261
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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