Anti-MAML2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Lieferant: Bioss
BS-12397R-A680
BOSSBS-12397R-A680EA 890 EUR
BOSSBS-12397R-A680
Anti-MAML2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Antikörper
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans. The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster. In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells. The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies. Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1. Mam1 is an essential component of the transcriptional apparatus of Notch Signalling. The gene which encodes Mam1 maps to human chromosome 5.

Type: Primary
Antigen: MAML2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 121-220/1156
Host: Rabbit
Isotype: IgG
Reactivity:
Bestellen

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mehr About VWR