Anti-APC2 Rabbit Polyclonal Antibody (Cy3®)

Lieferant: Bioss
BS-12485R-CY3
BOSSBS-12485R-CY3EA 900 EUR
BOSSBS-12485R-CY3
Anti-APC2 Rabbit Polyclonal Antibody (Cy3®)
Antikörper
The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: APC2
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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