Anti-ABH1/ALKB Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-12565R-A750
BOSSBS-12565R-A750EA 890 EUR
BOSSBS-12565R-A750
Anti-ABH1/ALKB Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumour DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Type: Primary
Antigen: ABH1/ALKB
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 1-100/389
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat
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