Anti-ALKBH1 Rabbit Polyclonal Antibody (Cy5®)

Lieferant: Bioss
BS-12565R-CY5
BOSSBS-12565R-CY5EA 900 EUR
BOSSBS-12565R-CY5
Anti-ALKBH1 Rabbit Polyclonal Antibody (Cy5®)
Antikörper
ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ALKBH1
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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