Anti-CSTF3/CSTF77 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-12935R-A750
BOSSBS-12935R-A750EA 890 EUR
BOSSBS-12935R-A750
Anti-CSTF3/CSTF77 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. Heterotrimeric CstF recognizes GU- and U-rich sequences located downstream of the polyadenylation site on RNA. CstF-77 (cleavage stimulation factor, 77 kDa subunit), also known as CstF3, is one of the three subunits comprising CstF. It can exist as a homodimer and functions as the bridge, directly interacting with the other two CstF subunits, namely CstF-64 and CstF-50. CstF-77 is highly conserved among eukaryotes. It contains an Alpha-helical structure with 11 HAT (Half-a-TPR-containing) repeats and is essential for CstF assembly. In addition, CstF-77 is capable of interacting with CPSF1 and FCP1, other factors involved in polyadenylation.

Type: Primary
Antigen: CSTF3/CSTF77
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 151-250/717
Host: Rabbit
Isotype: IgG
Reactivity: Mouse
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