Anti-CSK Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Lieferant: Bioss
BS-12941R-A555
BOSSBS-12941R-A555EA 893 EUR
BOSSBS-12941R-A555
Anti-CSK Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Antikörper
All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CSK
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype:
Reactivity:
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