Anti-Exonuclease 1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-13119R-A750
BOSSBS-13119R-A750EA 890 EUR
BOSSBS-13119R-A750
Anti-Exonuclease 1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
Comparative evaluation of the expression patterns of the human and mouse genes, combined with previous biochemical and yeast genetic studies, indicate that the Exo1 (Exonuclease I) proteins are important contributors to chromosome processing during mammalian DNA repair and recombination. In mice, the Exo1 gene maps to distal chromosome 1, consistent with the recent mapping of the orthologous human HEX1/EXO1 gene to chromosome 1q43. Exo1 is expressed prominently in testis, an area of active homologous recombination, and spleen, a prominent lymphoid tissue. In both mammalian and yeast systems, Exo1 is a 5'-3' double stranded DNA exonuclease that has previously been implicated in DNA mismatch repair (MMR). The MMR system ensures genome integrity by removing mispaired and unpaired bases that originate during replication. In humans, Exo1 interacts with MSH2 and MLH1 and has been proposed to be a redundant exonuclease in MMR. In both mammalian and yeast systems, Exo1 plays a structural role in MMR and stabilises multiprotein complexes containing a number of MMR proteins.

Type: Primary
Antigen: Exonuclease 1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 31-130/846
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse
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