Anti-EXOSC10/PMSCL2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-13120R-A750
BOSSBS-13120R-A750EA 890 EUR
BOSSBS-13120R-A750
Anti-EXOSC10/PMSCL2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3? region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3?-5? enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.

Type: Primary
Antigen: EXOSC10/PMSCL2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 41-140/885
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse
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