Anti-CFI Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Lieferant: Bioss
BS-13131R-A488
BOSSBS-13131R-A488EA 893 EUR
BOSSBS-13131R-A488
Anti-CFI Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Antikörper
The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins; Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CFI
Clonality: Polyclonal
Clone: 0
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity:
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