Anti-SKAP1 Rabbit Polyclonal Antibody (Cy3®)

Lieferant: Bioss
BS-13702R-CY3
BOSSBS-13702R-CY3EA 900 EUR
BOSSBS-13702R-CY3
Anti-SKAP1 Rabbit Polyclonal Antibody (Cy3®)
Antikörper
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines. SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: SKAP1
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat
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