Anti-C-SKI/v-SKI Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-1684R-A750
BOSSBS-1684R-A750EA 890 EUR
BOSSBS-1684R-A750
Anti-C-SKI/v-SKI Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.

Type: Primary
Antigen: C-SKI/v-SKI
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 551-650/728
Host: Rabbit
Isotype: IgG
Reactivity:
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