Anti-WNT5A Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-1948R-A750
BOSSBS-1948R-A750EA 899 EUR
BOSSBS-1948R-A750
Anti-WNT5A Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Type: Primary
Antigen: WNT5A
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 301-381/381
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Dog
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