Anti-ALOX5 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Lieferant: Bioss
BS-3251R-A555
BOSSBS-3251R-A555EA 921 EUR
BOSSBS-3251R-A555
Anti-ALOX5 Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Antikörper
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ALOX5
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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