Anti-5-Lipoxygenase Ser271 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-3251R-A750
BOSSBS-3251R-A750EA 917 EUR
BOSSBS-3251R-A750
Anti-5-Lipoxygenase Ser271 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyses the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Type: Primary
Antigen: 5-Lipoxygenase Ser271
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Rat
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