Anti-RAD21 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Lieferant: Bioss
BS-4284R-A647
BOSSBS-4284R-A647EA 893 EUR
BOSSBS-4284R-A647
Anti-RAD21 Rabbit Polyclonal Antibody (Alexa Fluor® 647)
Antikörper
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: RAD21
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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