Anti-ETS1 associated protein 2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Lieferant: Bioss
BS-5164R-A680
BOSSBS-5164R-A680EA 890 EUR
BOSSBS-5164R-A680
Anti-ETS1 associated protein 2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Antikörper
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. catalyses the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. hydrolyses 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.

Type: Primary
Antigen: ETS1 associated protein 2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 201-300/362
Host: Rabbit
Isotype: IgG
Reactivity: Mouse
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